| PATENT CLAIMS |
An ex vivo renal tubule tissue system prepd by process comprising culturing kidney cells in culture medium comprising all-trans retinoic acid, TGF-beta1 & epidermal growth factor in amount effective for achieving tubulogenesis wherein tubulogenesis is a phenotypic transformation of said cells such that condensed aggregates of tubule cells form about a central lumen wherein said lumen is bordered by cells possessing a polarized epithelial phenotype with extensive microvilli formation & tight junctional complexes along the lumenal border
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