| PATENT ASSIGNEE'S COUNTRY | USA |
| UPDATE | 04.00 |
| PATENT ASSIGNEE |
Scriptgen Pharma. University of Massachusetts Medical Center (Worcester) |
| PATENT CLAIMS |
- Contacting purified pX protein of HBV with (i) purified trans cription factor comprising a bZIP domain & (ii) purified oligo duplex comprising target DNA seq of said factor, in presen ce of test compd to form test mixt - Contacting said pX protein with transcription factor & oligo duplex in absence of test compd to form control mixt - Incubating both mixt to allow pX-mediated dimerization & DNA binding of transcription factor to occur - Determn level of DNA binding of transcription factor in each of mixt - Comparing - Selecting as inhibitor any test compd that causes decrease in level of binding |
| PATENT PHOTOCOPY | Available on request |
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