Main > NEUROLOGY. > Creutzfeldt-Jakob Disease > Prion Protein > Detection > Transgenic Mice's Use

Product USA. U. No. 2

PATENT ASSIGNEE'S COUNTRY USA
INVENTOR This data is not available for free
PATENT ASSIGNEE This data is not available for free
PATENT CLAIMS Transgenic mouse comprising
- Genome wherein both alleles of endogenous PrP gene
are ablated
- Transgene expressing an exogenous PrP gene from a
genetically diverse mammal selected from group: cow,
sheep & human
Wherein the mouse is susceptible to infection with prions which generally will only infect diverse test mammal of the species from which exogenous PrP gene was obtained, & further wherein the mouse exhibits symptoms of prion disease within < 200 days after inoculation
PATENT PHOTOCOPY Available on request

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