| CORP. SALE |
Identification & characterization of Enediyne C-1027 biosynthetic production genes has been carried out. The researchers cloned the genes & demonstrated that the yield may be improved by manipulating the biosynthetic pathway |
| MECHANISM OF ACTION | In C-1027, the protein wraps around the enediyne, sequesters & stabilizes it, & shepherds it out of the cell, thus protecting the producing bacterium from potential lethal exposure to the enediyne's toxic fury |
| UPDATE | 03.00 |
| USES |
The enediyne easily cyclizes to the 1,4-benzenoid diradical intermediate. The diradical is species responsible for oxidative DNA cleavage; therefore there is interest in developing - Enediyne-based anticancer drugs & - Enediyne-based antibiotics |
| AUTHOR | This data is not available for free |
| LITERATURE REF. | This data is not available for free |
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