| CLINICAL STUDY | Antidotes to treat Shiga toxin in the gut are in trial |
| INDICATION'S | Possible treat. of Shiga toxin (I) infection; once (I) enters the bloodstream; an event that can trigger kidney toxicity & death |
| MECHANISM OF ACTION |
Infection caused by "Shigella dysenteriae" bacteria's Shiga toxin made up of 2 subunits B subunit binds to mammalian cells, allowing A unit gain entry & do the toxin's dirty work. A strain of E. coli has picked up the gene for Shiga toxin, expressing it as the "hamburger toxin" that's proven deadly in undercooked meat E. coli strain: 0157:H7 Shiga toxin's B unit made up of 5 monomers each of which has 3 binding sites. The pentamer locks onto cells by gripping > 5 carbohydrate ligands simultaneously |
| STATUS |
Researchers are gearing up to produce STARFISH in sufficient quantities to explore the possibility (See Indication) in animal models |
| TECHNOLOGY |
Developed STARFISH: Structure based on attachment of TRISACCHARIDE DIMER on each of 5 spokes on core [GLUCOSE] in the hopes of 'hitting' 10 binding sites on 5 monomers. Only 5 of Starfish's trisaccharide arms are engaged, leaving the other 5 free to bind another B subunit. The upshot is that Starfish is sandwiched between 2 subunits |
| UPDATE | 02.00 |
| AUTHOR | This data is not available for free |
| LITERATURE REF. | This data is not available for free |
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