| CORP. SALE |
Result of amide-formation condensation between - Dihydro-Benzopyran-2,5,6,8-tetra-Me-7-OH-2-COOH (Anti oxidant function) - Piperazine-4-[C6H4-NH-C(=NH)-(2'-thiophenyl)] (NO produc tion inhibitor function) |
| CLINICAL STUDY | The compd reduced brain damage in mice & other rodents whose blood supply to the brain had been cut off |
| DESCRIPTION | The compd could be administered as much as 8 hours after the head injury & still protect against nerve damage |
| INDICATION'S | Protection nerve cells from damage after a stroke or head injury |
| MECHANISM OF ACTION |
Both NO & reactive O moieties such as superoxide build up in the cells of the brain when the blood supply is cut off, as happens in stroke or certain head injuries. Both agents can kill the cells; the agents can also react with each other to produce peroxynitrite (ONOO anion), which is more damaging to nerve cells. The researchers have produced a bifunctional molecule by joining an ANTIOXIDANT molecule with NO INHIBITOR molecule |
| UPDATE | 09.99 |
| AUTHOR | This data is not available for free |
| LITERATURE REF. | This data is not available for free |
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