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Section:	Main.NEUROLOGY..Alzheimer's Disease.Beta Secretase [BACE1 (Abbrev.)].Aspartyl Protease 2 (Asp2)..Patent.Claims Etc.Claim 1: Isolated Polynucleotide.Nucleotide Seq. Hybridizes under.Following Stringent Hybridization.Conditions to Complement of SEQ ID.NO:3: (1) Hybridization at 42C;.Buffer: 6.times.SSC and 0.1% SDS &.(2) Wash at 65C in Soln.:.1.times.SSC and 0.1% SDS; Wherein.Polynucleotide Encodes Polypeptide.; Contiguous AA Seq. Includes.Aspartyl Protease Active Site.Tripeptides DTG & DSG & Exhibits.Aspartyl Protease Activity Involved.in Processing APP into Amyloid Beta.Lacks a Transmembrane Domain..Claim 2: Isolated Polynucleotide.; Nucleotide Seq. Encoding Protein.Comprises Fragment of Asp2 AA Seq..SEQ ID NO: 4; Contiguous Fragment.SEQ ID NO: 4 Includes Aspartyl.Protease Activity Involved in.Processing APP into Amyloid Beta &.Lacks a Transmembrane Domain..Claim 3: Heterologous Peptide Tag.Claim 4: Isolated Polynucleotide.Nucleotide Seq. Encodes a Signal.Peptide Fused In-Frame to Polypepti.de Comprise Fragment of Asp2 Protei.n AA Seq. of SEQ ID NO: 4: Wherein.Continuous Fragment Includes.Aspartyl Protease Active Site Tripe.ptides DTG & DSG; Wherein Signal.Peptide Promotes Extracellular Secr.etion in Host Cell Transfected with.Polynucleotide; & Polypeptide is.Secreted by Host Cell & Exhibits.Aspartyl Protease Activity Involved.in Processing APP into Amyloid Beta.Claim 5: Isolated Polynucleotide.Cl. 1,2,4; Fragment of SEQ ID NO: 3.Claim 6: Vector: Polynucleotide Cl..1,2,4. Claims 7,8: Host Cell Transf.ormed with Polynucleotide/Vector.resp. Cl. 1,2,4. Claim 9: Expressio.n Vector; Polynucleotide Linked to.Heterologous Expression Control Seq
Code:	63501
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