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Section:	Main.NEUROLOGY..Alzheimer's Disease.Beta Secretase [BACE1 (Abbrev.)].Aspartyl Protease 2 (Asp2)..Inhibitor..Identification Method..Patent..Claims Etc.Claim 1: Method Identifying Agent.Modulates Activity of Asp2 Aspartyl.Protease, Comprising the Steps: a).Contacting Asp2 Aspartyl Protease.with APP in Presence & Absence of.Test Agent; Asp2 Aspartyl Protease.Recombinant Polypeptide Exhibits.Asp2 Aspartyl Protease Activity.Involved in Processing APP into.Amyloid Beta & Expressed by Host.Cell Transformed with Nucleic Acid.Molecule that Encodes Polypeptide., Hybridizes at Following Stringent.Hybridization Conditions to.Complement of SEQ ID NO: 3: (1).Hybridization at 42C; Buffer:.6.times.SSC & 0.1% SDS. (2) Wash.at 65C in Soln.: 1.times.SSC &.0.1% SDS; b) Determine APP.Processing Activity Asp2 Aspartyl.Protease in Presence & Absence of.Test Agent & c) Identify Test Agent.as Inhibitor if Protease Activity.is Decreased in Pres. Test Agent..Claim 2: Human Isoform of APP..Claim 3: APP Beta-Secretase Cleavag.e Site. Swedish Mutation.(K.fwdarw.N, M.fwdarw.L). Claim 4:.APP Carboxy-Terminal Di-Lysine (KK).Claim 5: APP Expressed in Byte Cell.Claim 6: Method Identifying Agent.Inhibits APP Processing Activity of.Protease Steps: a) Contact Protease.with APP in Pres. & Absence Test Ag..; Protease is Recombinant Protein.Expressed by Cell Transformed.with Nucleic Acid Comprising.Nucleotide Seq. Encoding Protease.; Wherein Protease AA Seq. > 95%.Identical to Asp2 AA Seq. SEQ ID NO.: 4 or Fragment Thereof Includes.Aspartyl Protease Active Site.Tripeptides DTG & DSG Exhibits.Asp2 Aspartyl Protease Activity
Code:	63493
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