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Section:	Main.NEUROLOGY..Alzheimer's Disease.Beta Secretase [BACE1 (Abbrev.)].Aspartyl Protease 2 (Asp2)..Inhibitor..Identification Method..Patent..Claims Etc.Claim 1: Method Identifying Agent.Modulate Activity Asp2 Aspartyl.Protease Comprising Steps: a).Contact Asp2 Aspartyl Protease with.APP in Presence & Absence of Test.Agent; Asp2 Aspartyl Protease is.ReCombinant protein Exhibits.Asp2 Aspartyl Protease Activity.Involved in Processing APP into.Amyloid Beta & Expressed by Host.Cell Transformed with Nucleic Acid.Molecule Encodes Protein & that.Hybridizes at Following Stringent.Hybridization Conditions to the.Complement of SEQ ID NO: 5: (1).Hybridization at 42C in Buffer:.6.times.SSC & 0.1% SDS & (2) Wash.at 65C in Soln.: 1.times.SSC &.0.1% SDS; b) Determine APP.Processing Activity Asp2 Aspartyl.Protease in Presence & Absence of.Test Agent & c) Identify Test Agent.as Inhibitor if Protease Activity.is Decreased in Pres. of Test Agent.Claim 2: APP Beta-Secretase Cleavag.e Site Comprise: Swedish Mutation.(K.fwdarw.N, M.fwdarw.L). Claim 3:.Cl. 1a: Growing Transformed Cells.in Presence & Absence of Test Ag..Claim 4: APP Expressed by Cell..Claim 5: Cl. 4 Determining Step Com.prise Measuring Production of.Amyloid Beta Peptide by Cell in.Presence & Absence of Test Agent.Claim 6: Host Cell:.Human Embryonic Kidney Cell Line.293 (HEK293) Cell. Assignee
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