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Section:	Main.NEUROLOGY..Alzheimer's Disease.Beta Secretase [BACE1 (Abbrev.)].Aspartyl Protease 2 (Asp2)..Inhibitor..Identification Method..Patent..Claims Etc.Claim 1: Purified Protein AA Seq.:.SEQ ID NO: 73 Aspartyl Protease.Activity toward APP. Claim 2:.Protein Lacks Transmembrane Domain.Claims 3,4: Includes Heterologous.Peptide Tag. Claims 5,6: Protein.Production Method. Culturing.Host Cell Transformed with Nucleic.Acid EnCoding SEQ ID NO: 73 Protein.& Isolating Expressed Protein..Claim 7: Asp2 Inhibitor Identifying.Method: a) Measure Proteolytic.Activity of Asp2 in Pres. & Absence.of Test Ag.; b) Decreased Activity.in pres. of Ag. Identifies Ag. as.Inhibitor. Claim 8: Cl. 7a Proteoly.tic Activity of Asp2 Measured.toward APP Substrate. Assignee
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