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Main.PHARMA..Quinolinone..FloseQuinan..Halogenated FloseQuinan..Chlorinated FloseQuinan.MonoChloro FloseQuinan..Patent..Claims Etc.Claim 1: Racemic ChloroFloseQuinan.Claim 2: (S)-(+)-ChloroFloseQuinan.in Enantiomeric Excess. Claims 3,4:.(S)-(+)-FloseQuinan in > 90,95%.resp. ee. Claim 5:.R)-(-)-FloseQuinan in ee. Claims 6,.7: R)-(-)-FloseQuinan in 90,95%.resp. in ee. Claim 8:.3-Cl-Me-Sulfonyl-7-F-1-Me-4-Quinolo.ne. Claim 9: 3-Cl-Me-Thio-7-F-1-Me-.4-Quinolone. Claim 10:.ChloroDesOxyFloseQuinan Synthesis.b) FloseQuinan+(Ph)3P Reaction=.DesOxyFloseQuinan (D).(7-F-1-Me-3-Me-Thio-4-Quinolone) in.Org. Solv.; c) (D)+N-Cl-Succinimide.+2,2-AzoBisIsobutyroNitrile=.ChloroDesOxyFloseQuinan (C).(3-Cl-Me-Thio-7-F-1-Me-4-Quinolone).in Org. Solv. Claim 11: (b) Solv..Select: CCl4 Etc. Claim 15:.(c) Solv. Select: CCl4 Etc. Claim.17: MonoChloroFloseQuinan Synthesis.: ChloroDesOxyFloseQuinan+H2O2+.K2CO3 in CCl4 Solv. Reaction..Patent Assignee |