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Section:	Main.PEPTIDES.Amylin..Amylin Amide..Patent..Claims.Claim 1: Prepn Peptide C-End Amide.a) Treat Soln of Peptide Acid Form.with an Esterifying Reagent to form.Peptide Ester (A); b) Treat. (A):.NH2 Source+Chymotrypsin. Claim 2:.Cl. 1(b) Step: (A)+NH2 Source+.Enzyme Select: Thermolysin, Papain,.Pepsin and Bromelain. Claim 3:.Amylin C-End Amide Prepn.: a).Idem to Cl. 1,2; b) (A)+NH2 Source+.Amidation Reagent: Enzyme & c).Remove Ester Groups from Side Chain.Carboxyls. Claim 4: NH2 Source:.Amine & Enzyme: Chymotrypsin..Claim 5: NH2 Source: Amine &.Enzyme Select: Thermolysin, Papain,.Pepsin, and Bromelain. Claim 6:.NH2 Source: Amino Acid-Amide &.Enzyme: CarboxyPeptidase Y..Claim 7: Esterification Reagent:.Alcohol+Acid. Claim 8: Amylin..Claim 9: Human Amylin. Claim 10:.Analog of Human Amylin. Claims 11,.12: Peptide Acid Form is.Amylin.sup.1-36 Gly-COOH;.Amylin.sup.1-36 Ala-COOH resp..Patent Assignee
Code:	62017
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