|KALLIKREIN||One of a group of plasma serine proteases that catalyze the formation of ki
nins from kininogens.
Kallikrein can also initiate the intrinsic pathway of blood clotting
|KAPPA OPIOID RECEPTOR||The .kappa. receptors have a wide distribution in CNS and mediate a spectrum of functions including the modulation of drinking, water balance, food intake, gut motility, temperature control and various endocrine functions. They also produce analgesia. ›See, for example: Leander et al, J. Pharmacol. Exp. Ther. 234, 463-469, 1985; Morley et al, Peptides 4, 797-800, 1983; Manzanares et al, Neuroendocrinology 52, 200-205, 1990; and Iyengar et al, J. Pharmacol. Exp. Ther, 238, 429-436, 1986.!
Most clinically used opioid analgesics such as morphine and codeine act as .mu. receptor agonists. These opioids have well-known, undesirable and potentially dangerous dependence forming side effects. Compounds which are .kappa.-receptor agonists act as analgesics through interaction with .kappa. opioid receptors. The advantage of these agonists over the classical .mu. receptor agonists, such as morphine, lies in their ability to cause analgesia while being devoid of morphine-like behavioral effects and addiction liability
|KHARASCH CHEMISTRY||the combination of a polychlorinated alkane with an olefin to produce a chlorinated or hydrochlorinated alkane with the use of a transition metal compound in homogeneous solution as catalyst|
|KINASE||An enzyme that catalyzes the transfer of a phosphoryl group from ATP, & occasionally from other nucleoside triphosphates to another compd.
Any of several enzymes that catalyze the transfer of a phosphate group from one molecule to another
|KININ||One of a group of vasoactive peptide hormones that are formed from kinino
gens by the action of enzymes known as kallikreins.
Kinins are potent vasodilators, leading to an increase in the diam. of blood vessels, hypotension, & increased capillary permeability.
Bradykinin is a nonapeptide & kallidin (lysyl bradykinin) is a decapeptide
|KINUGASA REACTION||Beta-Lactam prepn. through coupling of alkynes with nitrones|
|KNOCK IN MICE||TransGenic Mice with Increased Human Gene Activity|
|KNOCK OUT MICE||TransGenic Mice in which Function of Human Gene of Interest is Deleted|
|KONDO RESONANCE (electronics)||a strong correlation between the spin on the cobalt ion and the spins of the electrons in the electrodes.|
|KRAFT PROCESSING||high-temperature and high-pressure procedures in which wood chips are digested in caustic sulfurous solutions.|
|KRILL||generic term used to designate all deepwater marine planktonic crustacean species. It looks like miniature shrimp, ranging between one and six centimeters in length. These 85 species represents the planet's most abundant animal biomass found in banks that may extend over several square kilometers. Krill fisheries can mainly be found in two ocean regions: the Antarctic Ocean and the North Pacific Ocean, along the Canadian and Japanese coasts. According to a World Health Organization estimate, the total quantity of krill in these two oceans exceeds 500 million tons. Approximately 110,000 tons of krill are harvested every year, or about less than one-half of 0.1% of the existing resources.|
|KROLL PROCESS||At present, titanium is produced by a pyrometallurgical reduction batch process known as the Kroll process. The Kroll process involves chlorinating titanium dioxide to produce titanium tetrachloride. TiCl4 is then reduced to the metal with metallic magnesium|