Main > PHARMA. > Chiral Pharmaceuticals > Enantiomeric Excess Determn. > Org.: NE. G. (Research) > Report Abstract

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has reported a rapid screening technique to estimate enantiomeric excesses of reaction mixtures. The screening is a visual scan of the color of reflected light from 96-well titer plates in which various catalyst candidates have effected an enantioselective reaction. Author s method makes use of the fact that the degree of helical twist of molecular ordering in nematic liquid crystals is affected by chiral dopants. He uses a commercially available mixture, called E7, from EM Industries, Darmstadt, Germany. He makes derivatives of the chiral compounds with other liquid-crystal-forming molecules to use in doping E7.



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